公开(公告)号：US20240400645A1

公开(公告)日：2024-12-05

申请号：US18656168

申请日：2024-05-06

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Ekta SETH CHHABRA ,  Alison INNES ,  Dan RUDIN ,  Kara RICE ,  Nancy WONG ,  Suresh KATRAGADDA

IPC: C07K14/755 ,  A61K38/00 ,  A61P7/04

Abstract: The present disclosure provides a method of treating hemophilia A in a human subject in need thereof comprising administering to the subject a chimeric polypeptide comprising (i) a factor VIII (FVIII) protein and (ii) a von Willebrand factor (VWF) fragment comprising a D′ domain of VWF and a D3 domain of VWF at a dosing interval.