公开(公告)号：US20240287158A1

公开(公告)日：2024-08-29

申请号：US18572006

申请日：2022-06-23

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Tyler CARLAGE ,  Randall MAULDIN ,  Loubna Mzaalak TAZI ,  Timothy R. MCCOY

IPC: C07K14/755 ,  A61K38/00 ,  A61K47/02 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26

CPC classification number: C07K14/755 ,  A61K47/02 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26 ,  A61K38/00 ,  C07K2319/30

Abstract: The present disclosure provides pharmaceutical compositions of a chimeric protein comprising a factor VIII (FVIII) polypeptide and a von Willebrand factor (VWF) polypeptide. Also disclosed are pharmaceutical kits and methods of using the disclosed pharmaceutical compositions to treat hemophilia A.

公开(公告)号：US20240358800A1

公开(公告)日：2024-10-31

申请号：US18632038

申请日：2024-04-10

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Tyler CARLAGE ,  Randall MAULDIN ,  Timothy MCCOY ,  Loubna Mzaalak TAZI

IPC: A61K38/37 ,  A61K9/00 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26

CPC classification number: A61K38/37 ,  A61K9/0019 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26

Abstract: The present disclosure provides pharmaceutical compositions of a chimeric protein comprising a factor VIII (FVIII) polypeptide and a von Wilobrand factor (VWF) polypeptide. Also disclosed are pharmaceutical kits and methods of using the disclosed pharmaceutical compositions to treat hemophilia A.