公开(公告)号：US20200087379A1

公开(公告)日：2020-03-19

申请号：US16521789

申请日：2019-07-25

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Volker Schellenberger ,  Pei-Yun Chang ,  Fatbardha Varfaj ,  Sheng Ding ,  Joshua Silverman ,  Chia-wei Wang ,  Benjamin Spink ,  Willem P. Stemmer ,  Nathan Geething ,  John Kulman ,  Tongyao Liu ,  Garabet G. Toby ,  Haiyan Jiang ,  Robert Peters ,  Deping Wang ,  Baisong Mei

IPC: C07K14/755

Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.

公开(公告)号：US10548953B2

公开(公告)日：2020-02-04

申请号：US14912047

申请日：2014-08-14

Applicant: Bioverativ Therapeutics Inc.

Inventor： Tongyao Liu ,  Pei-Yun Chang ,  John Kulman ,  Volker Schellenberger ,  Haiyan Jiang ,  Robert T. Peters ,  Ekta Seth Chhabra

IPC: A61K38/37 ,  A61K9/00 ,  C07K14/00 ,  C07K14/755 ,  C12N15/85 ,  A61K48/00

Abstract: The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.

公开(公告)号：US20230322900A1

公开(公告)日：2023-10-12

申请号：US18064571

申请日：2022-12-12

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Volker Schellenberger ,  Pei-Yun Chang ,  Fatbardha Varfaj ,  Sheng Ding ,  Joshua Silverman ,  Chia-wei Wang ,  Benjamin Spink ,  Willem P. Stemmer ,  Nathan Geething ,  John Kulman ,  Tongyao Liu ,  Garabet G. Toby ,  Haiyan Jiang ,  Robert Peters ,  Deping Wang ,  Baisong Mei

IPC: C07K14/755

CPC classification number: C07K14/755 ,  A61K38/00

Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.