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公开(公告)号：US11324220B2
公开(公告)日：2022-05-10
申请号：US16928493
申请日：2020-07-14
发明人： Chunhua Yang
IPC分类号： C07D453/04 , C07D261/04 , A01N43/80 , A01N43/42 , A61K31/42
摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
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公开(公告)号：US10750744B2
公开(公告)日：2020-08-25
申请号：US16182838
申请日：2018-11-07
发明人： Chunhua Yang
IPC分类号： C07D453/04 , C07D261/04 , A01N43/80 , A01N43/42 , A61K31/42
摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
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公开(公告)号：US20210022344A1
公开(公告)日：2021-01-28
申请号：US16928493
申请日：2020-07-14
发明人： Chunhua Yang
IPC分类号： A01N43/80 , C07D453/04 , C07D261/04 , A01N43/42 , A61K31/42
摘要： This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.
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