公开(公告)号：US3557111A

公开(公告)日：1971-01-19

申请号：US3557111D

申请日：1968-03-29

申请人： BOLA VITHAL SHETTY

发明人： SHETTY BOLA VITHAL

IPC分类号： C07D265/26 ,  C07D51/48

CPC分类号： C07D265/26 ,  Y10S514/869

摘要： A CLASS OF COMPOUND HAVING DIURETIC PROPERTIES HAS THE FOLLOWING FORMULA:

1-R1,2-R2,2-R2'',3-((R3,R3'',R3"-PHENYL)-(CH2)N-),5-R5,6-

(R6-N(-R6'')-SO2-),7-X,8-R8-1,2,3,4-TETRAHYDRO-

QUINAZOLIN-4-ONE

INCLUDING THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, IN WHICH X IS HALOGEN OR TRIFLUOROMETHYL; R6 AND R6'' ARE LOWERALKYL, PHENYL, OR PHENYLLOWERALKYL; OR R6 IS HYDROGEN AND R6'' IS ACYL SUCH AS ACETYL OR C3H7CO, OR PHENYLLOWERALKYL OR PHENYLLOWERALKYL; R2 AND R2'' ARE HYDROGEN, LOWERALKYL, LOWERALKENYL, THIOLOWERALKYL, ALKYLTHIO, HALOGEN SUBSTITUTED LOWERALKYL, PHENYLALKYL, PHENYL, CYCLOALKYL, CYCLOALKYLLOWERALKYL, LOWERALKOXY, LOWERALKOXYLOWERALKYL, OR R2 AND R2'' TOGHETHER ARE LOWER POLYMETHYLENE CHAIN MORPHOLINO, PYRROLIDINO, OR PIPERAZINO; R1 IS HYDROGEN, PHENYLALKYL, HYDROXYALKYL, LOWERALKOXYLOWERALKYL, OR LOWERALKYL; R5 AND R8 ARE HYDROGEN, LOWERALKYL, AMINO, LOWERALKOXY, OR LOWERALKOXYLOWERALKYL; R3, R3'', AND R3" ARE HYDROGEN, LOWERALKYL, HYDROXY, LOWERALKOXY, LOWERALKOXYLOWERALKYL, HALOGEN, TRIFLUOROMETHYL, SULFAMYL, OR AMINO, AND N IS AN INTEGER FROM 0-4.