公开(公告)号：US20170348401A1

公开(公告)日：2017-12-07

申请号：US15536458

申请日：2015-12-21

申请人： BRACCO SUISSE SA

发明人： Gilles BIOLEY ,  Philippe BUSSAT ,  Blaise CORTHESY ,  Anne LASSUS

IPC分类号： A61K39/00

摘要： Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention, comprising a molar excess of fatty acids in the stabilizing envelope, are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.