公开(公告)号：US3654265A

公开(公告)日：1972-04-04

申请号：US3654265D

申请日：1970-11-27

申请人： BRISTOL MYERS CO

发明人： ESSERY JOHN MICHAEL ,  WEST JANET RUTH

IPC分类号： C07D499/00 ,  C07D499/32 ,  C07D499/68 ,  C07D99/12

CPC分类号： C07D499/00

摘要： PIVALOYLOXYMETHYL 6 - (D -A - SULFOAMINOPHENYLACETAMIDO) PENICILLANATE SODIUM SALT (I) IS A VALUABLE ANTIBIOTIC AGENT, NUTRITIONAL SUPPLEMENT IN ANIMAL FEED, THERAPEUTIC AGENT IN POULTRY AND ANIMALS, INCLUDING MAN, AND IS ESPECIALLY USEFUL IN THE TREATMENT OF INFECTIOUS DISEASES CAUSED BY GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA, MOST PARTICULARLY THOSE CAUSED BY THE PSEUDOMONAS GENUS, SODIUM PIVALOYLOXYMETHYL 6-(D-A-SULFOAMINOPHENYLACETAMIDO)PENICILLANATE IS PREPARED BY THE TREATMENT OF DISODIUM 6-(D-A-SULFOAMINOPHENYLACETAMIDO) PENICILLANATE (II) WITH CHLOROMETHYL PIVALATE IN HEXAMETHYLPHOSPHORTRIAMIDE. COMPOUND I HAS A SIMILAR ANTIBACTERIAL SPECTRUM TO THAT OF COMPOUND II BUT IS ABSORBED FROM THE GASTRO-INTESTINAL TRACT 2-3 FOLD MARE EFFICIENTLY THAN COMPOUND II.