公开(公告)号：US20200069644A1

公开(公告)日：2020-03-05

申请号：US16612438

申请日：2018-05-22

Applicant: BRISTOL- MYERS SQUIBB COMPANY

Inventor： Jacek Ostrowski ,  Ricardo Garcia ,  Nicholas R. Wurtz ,  Nancy Lersey CARSON

IPC: A61K31/4015 ,  A61K45/06 ,  A61P9/04

Abstract: The disclosure generally relates to methods of treating heart failure with Compound 1, 1-((3S,4R)-4-(2,6-difluoro-4-meth oxyphenyl)-2-oxopyrrolidin-3-yl)-3-phenylurea.

公开(公告)号：US20180325869A1

公开(公告)日：2018-11-15

申请号：US15776927

申请日：2016-11-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jacek Ostrowski ,  Ricardo Garcia ,  Nicholas R. Wurtz

IPC: A61K31/4152 ,  A61P9/10 ,  A61P9/04

CPC classification number: A61K31/00 ,  A61K31/4152

Abstract: The disclosure generally relates to a therapeutic approach based on the stimulation of resolution of inflammation by the Formyl-Peptide Receptor 2/Lipoxin A4 receptor (FPR2/ALX) for the treatment of heart disease.