公开(公告)号：US11597721B2

公开(公告)日：2023-03-07

申请号：US16982937

申请日：2019-03-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zili Xiao ,  Michael G. Yang ,  Chunjian C. Liu ,  Trevor C. Sherwood ,  John L. Gilmore ,  David S. Weinstein

IPC: C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D513/04

Abstract: Compounds having the following formula (I) or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.

公开(公告)号：US20210032220A1

公开(公告)日：2021-02-04

申请号：US16982937

申请日：2019-03-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zili Xiao ,  Michael G. Yang ,  Chunjian C. Liu ,  Trevor C. Sherwood ,  John L. Gilmore ,  David S. Weinstein

IPC: C07D401/14 ,  C07D417/14 ,  C07D513/04 ,  C07D413/14

Abstract: Compounds having the following formula (I) or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.