公开(公告)号：US20230119066A1

公开(公告)日：2023-04-20

申请号：US17914257

申请日：2021-03-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ruth Yin-Zong Lan ,  Olufemi A. Adelakun ,  Ishita Barman ,  Joseph Campbell ,  SJ Jian Zhe Diong ,  Felix Findeisen ,  Danielle M. Greenawalt ,  Renu Jain ,  Amy D. Jhatakia ,  John K. Lee ,  Peter S.K. Lee ,  Linda Liang ,  Kai Lu ,  Bryan McDonald ,  Paul Mesko ,  Arvind Rajpal ,  Sharmila Sambanthamoorthy ,  Mark J. Selby ,  Nathan O. Siemers ,  Pavel Strop ,  Gaby A. Terracina ,  Xi-Tao Wang

IPC: C07K16/28 ,  A61P35/00

Abstract: This disclosure provides isolated antibodies, for example, monoclonal antibodies, that specifically bind to the C-C Motif Chemokine Receptor 8 (CCR8) expressed on the surface of a cell and mediate depletion of the CCR8-expressing cell by anti-body-dependent cellular cytotoxicity (ADCC). The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-CCR8 antibody as monotherapy or in combination with an anti-cancer agent such as an immune checkpoint inhibitor, for example, an anti-PD-1 or anti-PD-L1 antibody.