公开(公告)号：US11866430B2

公开(公告)日：2024-01-09

申请号：US17254914

申请日：2019-06-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Louis S. Chupak ,  Min Ding ,  Robert G. Gentles ,  Yazhong Huang ,  Scott W. Martin ,  Ivar M. Mcdonald ,  Stephen E. Mercer ,  Richard E. Olson ,  Upender Velaparthi ,  Michael Wichroski ,  Xiaofan Zheng

IPC: C07D471/04 ,  A61K31/4375 ,  A61P35/00

CPC classification number: C07D471/04 ,  A61K31/4375 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20210277004A1

公开(公告)日：2021-09-09

申请号：US17254914

申请日：2019-06-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Louis S. Chupak ,  Min Ding ,  Robert G. Gentles ,  Yazhong Huang ,  Scott W. Martin ,  Ivar M. Mcdonald ,  Stephen E. Mercer ,  Richard E. Olson ,  Upender Velaparthi ,  Michael Wichroski ,  Xiaofan Zheng

IPC: C07D471/04 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.