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公开(公告)号：US11866430B2
公开(公告)日：2024-01-09
申请号：US17254914
申请日：2019-06-26
发明人： Louis S. Chupak , Min Ding , Robert G. Gentles , Yazhong Huang , Scott W. Martin , Ivar M. Mcdonald , Stephen E. Mercer , Richard E. Olson , Upender Velaparthi , Michael Wichroski , Xiaofan Zheng
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
CPC分类号： C07D471/04 , A61K31/4375 , A61P35/00
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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公开(公告)号：US20210277004A1
公开(公告)日：2021-09-09
申请号：US17254914
申请日：2019-06-26
发明人： Louis S. Chupak , Min Ding , Robert G. Gentles , Yazhong Huang , Scott W. Martin , Ivar M. Mcdonald , Stephen E. Mercer , Richard E. Olson , Upender Velaparthi , Michael Wichroski , Xiaofan Zheng
IPC分类号： C07D471/04 , A61P35/00
摘要： Disclosed are compounds of Formula (I): or a salt thereof, wherein: R1, R2, R3, and R4 are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGK α) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
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