公开(公告)号：US11236049B2

公开(公告)日：2022-02-01

申请号：US16624490

申请日：2018-06-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jay Patrick Powers ,  Hilary Plake Beck ,  Maksim Osipov ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky ,  Tamar Rosenbaum ,  Ian Scott Young ,  Jennifer Nelson ,  Petinka Vlahova

IPC: C07D215/18 ,  A61K45/06

Abstract: The present disclosure relates to amorphous and crystalline forms of (R)-N-(4-chlorophenyl)-2-((1S,4S)-4-(6-fluoro-quinolin-4-yl) cyclohexyl)propanamide and its salts and hydrates, processes for their production, pharmaceutical compositions comprising them, and methods of treatment using them.