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公开(公告)号：US20190055320A1
公开(公告)日：2019-02-21
申请号：US16113061
申请日：2018-08-27
发明人： Nils LONBERG , Alan J. KORMAN , Bryan C. BARNHART , Aaron P. YAMNIUK , Mohan SRINIVASAN , Karla A. HENNING , Ming LEI , Emanuela SEGA , Angela GOODENOUGH , Maria JURE-KUNKEL , Guodong CHEN , John S. SACK , Richard Y. HUANG , Martin J. CORBETT , Joseph E. MYERS, JR. , Liang SCHWEIZER , Sandra V. HATCHER , Haichun HUANG , Pingping ZHANG
IPC分类号： C07K16/40 , G01N33/574 , A61K39/395 , A61K45/06 , C07K16/28 , C07K16/30 , A61K47/68 , A61K39/00
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.
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公开(公告)号：US20180127513A1
公开(公告)日：2018-05-10
申请号：US15520638
申请日：2015-11-19
发明人： Nils LONBERG , Alan J. KORMAN , Bryan C. BARNHART , Aaron P. YAMNIUK , Mohan SRINIVASAN , Karla A. HENNING , Ming LEI , Emanuela SEGA , Angela GOODENOUGH , Maria JURE-KUNKEL , Guodong CHEN , John S. SACK , Richard Y. HUANG , Martin J. CORBETT , Joseph E. MYERS, JR. , Liang SCHWEIZER , Sandra V. HATCHER , Haichun HUANG , Pingping ZHANG
IPC分类号： C07K16/40 , G01N33/574 , A61K39/395 , A61K45/06 , C07K16/28 , C07K16/30 , A61K47/68 , A61K39/00
CPC分类号： C07K16/40 , A61K39/39558 , A61K45/06 , A61K47/6871 , A61K2039/505 , C07K16/2896 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/57492 , G01N2333/916
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the disclosure, including methods for treating various cancers.
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公开(公告)号：US20190284293A1
公开(公告)日：2019-09-19
申请号：US16081115
申请日：2017-03-03
发明人： Nils LONBERG , Alan J. KORMAN , Bryan C. BARNHART , Aaron P. YAMNIUK , Mohan SRINIVASAN , Karla A. HENNING , Ming LEI , Emanuela SEGA , Angela GOODENOUGH , Maria JURE-KUNKEL , Guodong CHEN , John S. SACK , Richard Y. HUANG , Martin J. CORBETT , Joseph E. MYERS, Jr. , Liang SCHWEIZER , Sandra V. HATCHER , Rachel A. ALTURA , Haichun HUANG , Pingping ZHANG , Edward J. HILT , Michael Nathan HEDRICK
摘要： Provided are methods for clinical treatment of tumors (e.g., advanced solid tumors) using an anti-CD73 antibody in combination with an immuno-oncology agent, such as an anti-PD-1 antibody.
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公开(公告)号：US20170253665A1
公开(公告)日：2017-09-07
申请号：US15432180
申请日：2017-02-14
发明人： Nils LONBERG , Alan J. KORMAN , Bryan C. BARNHART , Aaron P. YAMNIUK , Mohan SRINIVASAN , Karla A. HENNING , Ming LEI , Emanuela SEGA , Angela GOODENOUGH , Maria N. JURE-KUNKEL , Guodong CHEN , John S. SACK , Richard HUANG , Martin J. CORBETT , Joseph E. MYERS, JR. , Liang SCHWEIZER , Sandra V. HATCHER , Haichun HUANG , Pingping ZHANG
IPC分类号： C07K16/40 , G01N33/573 , A61K39/395 , A61K45/06 , C07K16/30
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/72 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/573 , G01N2333/916
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.
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