公开(公告)号：US12187699B2

公开(公告)日：2025-01-07

申请号：US18300315

申请日：2023-04-13

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Joshua Hansen ,  Mimi L. Quan

IPC: C07D401/04 ,  A61K45/06 ,  A61P35/00 ,  C07D401/14 ,  C07D405/14

Abstract: Provided herein are compounds having the formula I for treating, preventing or managing cancer. Also provided are pharmaceutical compositions comprising the compounds and methods of use of the compounds and compositions. In certain embodiments, the methods encompass treating, preventing or managing cancer, including solid tumors and blood borne tumors using the compounds provided herein.

公开(公告)号：US20250092012A1

公开(公告)日：2025-03-20

申请号：US18948828

申请日：2024-11-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Joshua Hansen ,  Mimi L. Quan

IPC: C07D401/04 ,  A61K45/06 ,  A61P35/00 ,  C07D401/14 ,  C07D405/14

Abstract: Provided herein are compounds having the formula I for treating, preventing or managing cancer. Also provided are pharmaceutical compositions comprising the compounds and methods of use of the compounds and compositions. In certain embodiments, the methods encompass treating, preventing or managing cancer, including solid tumors and blood borne tumors using the compounds provided herein.

公开(公告)号：US20240208937A1

公开(公告)日：2024-06-27

申请号：US18501334

申请日：2023-11-03

Applicant: Bristol-Myers Squibb Company

Inventor： Thomas J. Cummins ,  Daniel K. Cashion ,  Jacob T. Edwards ,  Antonia Lopez-Girona ,  Joshua Hansen ,  Scott Arne Johnson ,  Mark A. Nagy ,  Kevin M. Oberg ,  Hannah L. Powers ,  Giorgio Tamo

IPC: C07D401/14 ,  A61K45/06 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D401/14 ,  A61K45/06 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: Disclosed herein are compounds and methods for the prevention and/or treatment of hemoglobinopathies. Also provided herein are such compounds for use in such methods. Also disclosed herein are pharmaceutical compositions comprising such compounds for use in such methods of preventing or treating hemoglobinopathies.

公开(公告)号：US20230331693A1

公开(公告)日：2023-10-19

申请号：US18300315

申请日：2023-04-13

Applicant: Bristol-Myers Squibb Company

Inventor： Joshua Hansen ,  Mimi L. Quan

IPC: C07D401/04 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  A61P35/00

CPC classification number: C07D401/04 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  A61P35/00

Abstract: Provided herein are compounds having the formula I




for treating, preventing or managing cancer. Also provided are pharmaceutical compositions comprising the compounds and methods of use of the compounds and compositions. In certain embodiments, the methods encompass treating, preventing or managing cancer, including solid tumors and blood borne tumors using the compounds provided herein.