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公开(公告)号：US10112944B2
公开(公告)日：2018-10-30
申请号：US15558724
申请日：2016-03-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lawrence R. Marcin , Stephen T. Wrobleski , T.G. Murali Dhar
IPC: C07D471/14
Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is CR6 or N; W is: (i) —(CR3R3)1-4— or (ii) —(CR3R3)x-Y—(CR3R3)y-; and Y, R1, R2, R3, R5, R6, R7, x, and y are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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Patent Agency Ranking
2.发明授权公开(公告)号：US11639353B2
公开(公告)日：2023-05-02
申请号：US17212210
申请日：2021-03-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Pratik Devasthale , Fang Moore , Guohua Zhao , Susan Nicole Pieniazek , Kumaravel Selvakumar , Suresh Dhanusu , Manoranjan Panda , Lawrence R. Marcin
IPC: C07D471/04 , A61K31/4375 , A61P1/16 , A61P13/12 , A61P11/00 , A61P35/00
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
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3.发明申请公开(公告)号：US20210246136A1
公开(公告)日：2021-08-12
申请号：US17212210
申请日：2021-03-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Pratik Devasthale , Fang Moore , Guohua Zhao , Susan Nicole Pieniazek , Kumaravel Selvakumar , Suresh Dhanusu , Manoranjan Panda , Lawrence R. Marcin
IPC: C07D471/04 , A61P1/16 , A61P13/12 , A61P11/00 , A61P35/00
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
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4.发明授权公开(公告)号：US09738642B2
公开(公告)日：2017-08-22
申请号：US15022072
申请日：2014-09-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lawrence R. Marcin , Mendi A. Higgins , Joanne J. Bronson , F. Christopher Zusi , John E. Macor , Min Ding
IPC: C07D471/04 , A61K31/437 , C07B59/00
CPC classification number: C07D471/04 , C07B59/002 , C07B2200/05
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system.
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5.发明申请TRIAZOLOPYRIDINE ETHER DERIVATIVES AND THEIR USE IN NEUROLOGICAL AND PYSCHIATRIC DISORDERS 审中-公开三唑并噻吩衍生物及其在神经病学和麻醉病中的应用公开(公告)号：US20160237081A1
公开(公告)日：2016-08-18
申请号：US15022072
申请日：2014-09-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Lawrence R. Marcin , Mendi A. Higgins , Joanne J. Bronson , F. Christopher Zusi , John E. Macor , Min Ding
IPC: C07D471/04 , C07B59/00
CPC classification number: C07D471/04 , C07B59/002 , C07B2200/05
Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system.
Abstract translation: 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物调节mGluR2受体并且可用于治疗中枢神经系统的各种疾病。
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6.发明授权公开(公告)号：US11014922B2
公开(公告)日：2021-05-25
申请号：US16347849
申请日：2017-11-07
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Pratik Devasthale , Fang Moore , Guohua Zhao , Susan Nicole Pieniazek , Kumaravel Selvakumar , Suresh Dhanusu , Manoranjan Panda , Lawrence R. Marcin
IPC: C07D471/04 , A61K31/4375 , A61P1/16 , A61P13/12 , A61P11/00 , A61P35/00
Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of av-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
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