公开(公告)号：US20240002513A1

公开(公告)日：2024-01-04

申请号：US18251935

申请日：2021-11-05

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Leonard P. JAMES ,  Yougan CHENG ,  Brian J. SCHMDIT ,  John J. ENGELHARDT ,  Li LI

IPC分类号： C07K16/28

CPC分类号： C07K16/2818 ,  C07K2317/41 ,  A61K2039/545

摘要： The present invention provides methods of dosing and administration of non-fucosylated anti-CTLA-4 antibodies, such as non-fucosylated ipilimumab, as monotherapy, and related compositions and dosage forms.

公开(公告)号：US20230192856A1

公开(公告)日：2023-06-22

申请号：US17998521

申请日：2021-05-11

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Leonard P. JAMES ,  Michelle BROWN

IPC分类号： C07K16/28

CPC分类号： C07K16/2818 ,  C07K2317/21 ,  C07K2317/565

摘要： The present invention provides methods of dosing and administration of an activatable anti-CTLA-4 antibody, such as an activatable ipilimumab.