公开(公告)号：US20190040080A1

公开(公告)日：2019-02-07

申请号：US15763281

申请日：2016-09-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Joanne J. BRONSON ,  Ling CHEN ,  Jonathan L. DITTA ,  Carolyn Diane DZIERBA ,  Prasada Rao JALAGAM ,  Guanglin LUO ,  John E. MACOR ,  Tarun Kumar MAISHAL ,  Susheel Jethanand Nara ,  Ramkumar RAJAMANI ,  Ramesh Kumar SISTLA ,  Soodamani THANGAVEL

IPC: C07D513/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28

Abstract: The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.