公开(公告)号：US20230295321A1

公开(公告)日：2023-09-21

申请号：US17934012

申请日：2022-09-21

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： MAREK HONCZARENKO ,  VAISHALI SHAH ,  LIXIN LANG ,  URVI ARAS ,  DIANE SHEVELL ,  CHRISTINE KRATT ,  KAREN PRICE ,  SUZANNE SUCHARD

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC分类号： C07K16/2875 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505

摘要： Methods of treating autoimmune diseases, such as primary immune thrombocytopenia (ITP), solid organ transplant rejection, graft-related disease, Pemphigus vulgaris, systemic sclerosis, and myasthenia gravis using antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The methods may comprise at least one administration cycle comprising one dose of the antibody polypeptide. The dose may be administered intravenously at a dose from about 75 mg to about 1500 mg. The method normalizes platelet counts in the human patient.