公开(公告)号：US20250084056A1

公开(公告)日：2025-03-13

申请号：US18882822

申请日：2024-09-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： DANIEL FERRANTE ,  ZHONGHUI LU ,  PETER KINAM PARK ,  JOHN S. TOKARSKI ,  VIPIN YADAV ,  MICHAEL G. YANG ,  JINYI ZHU ,  ANDREW P. DEGNAN ,  JAMES KEMPSON ,  RICHARD CHARLES BURRELL

IPC: C07D401/04 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  A61K45/06 ,  A61P35/00 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

Abstract: Disclosed are compounds of Formula (I): or stereoisomers, tautomers, or salts thereof, wherein: R is and Ring A, L, R1, R2, R3, m, and n are defined herein. Also disclosed are methods of using such compounds to decrease the level Cyclin E1; and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of proliferative disorders, such as cancer.

公开(公告)号：US20240002364A1

公开(公告)日：2024-01-04

申请号：US18461093

申请日：2023-09-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： CHUNJIAN LIU ,  MICHAEL G. YANG ,  ZILI XIAO ,  LING CHEN ,  RYAN M. MOSLIN ,  JOHN S. TOKARSKI ,  DAVID S. WEINSTEIN ,  STEPHEN T. WROBLESKI

IPC: C07D401/14 ,  C07D401/12 ,  C07D413/14 ,  C07D471/04 ,  C07D405/14 ,  C07F9/6558 ,  C07D417/14 ,  A61P37/00 ,  A61P29/00 ,  A61K31/501 ,  C07D487/04

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D413/14 ,  C07D471/04 ,  C07D405/14 ,  C07F9/65583 ,  C07D417/14 ,  A61P37/00 ,  A61P29/00 ,  A61K31/501 ,  C07D487/04

Abstract: Compounds having the following formula I:




or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.