公开(公告)号：US20170326247A1

公开(公告)日：2017-11-16

申请号：US15587927

申请日：2017-05-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Qiang CONG ,  Sanjeev GANGWAR ,  Vangipuram S. RANGAN ,  Mei-Chen SUNG

IPC: A61K47/68 ,  C07K16/28

CPC classification number: A61K47/6803 ,  A61K47/6811 ,  A61K47/6851 ,  C07K16/28 ,  C07K2317/565 ,  C07K2317/94

Abstract: The drug component of an antibody-drug conjugate having a structure according to formula (II), where Ab, m, n, R1, R2, R3, R4, and R5 are as defined in the application, exhibits unexpectedly improved stability.