公开(公告)号：US09688669B2

公开(公告)日：2017-06-27

申请号：US15026759

申请日：2014-10-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew P. Degnan ,  Darrell Maxwell ,  Matthew D. Hill ,  Haiquan Fang ,  Michael F. Parker ,  Fukang Yang ,  Joanne J. Bronson ,  John E. Macor

IPC: C07D413/14 ,  C07D413/04 ,  C07D263/24

CPC classification number: C07D413/04 ,  C07B2200/07 ,  C07D263/24 ,  C07D413/14

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be useful for the treatment of various disorders of the central nervous system.

公开(公告)号：US20160237072A1

公开(公告)日：2016-08-18

申请号：US15026759

申请日：2014-10-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew P. Degnan ,  Darrell Maxwell ,  Matthew D. Hill ,  Haiquan Fang ,  Michael F. Parker ,  Fukang Yang ,  Joanne J. Bronson ,  John E. Macor

IPC: C07D413/04 ,  C07D263/24 ,  C07D413/14

CPC classification number: C07D413/04 ,  C07B2200/07 ,  C07D263/24 ,  C07D413/14

Abstract: The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be useful for the treatment of various disorders of the central nervous system.

Abstract translation: 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 这些化合物是mGluR5受体的配体，激动剂和部分激动剂，并且可用于治疗中枢神经系统的各种疾病。