公开(公告)号：US12187723B2

公开(公告)日：2025-01-07

申请号：US17609443

申请日：2020-05-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar ,  Srinivasan Kunchithapatham Duraisamy ,  Pitani Veera Venkata Srinivas ,  Vikram Bhogadi ,  Subramanya Hegde

IPC: C07D471/04 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20220340555A1

公开(公告)日：2022-10-27

申请号：US17245595

申请日：2021-04-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  John L. Gilmore ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Pitani Veera Venkata Srinivas ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula

IPC: C07D471/04 ,  A61P19/02 ,  A61P25/00 ,  C07D495/10 ,  C07D519/00 ,  C07D491/107 ,  A61P37/00 ,  C07D471/08 ,  A61P29/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20250066344A1

公开(公告)日：2025-02-27

申请号：US18718477

申请日：2022-12-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Sreekantha Ratna Kumar ,  Pitani Veera Venkata Srinivas ,  Subramanya Hegde ,  Michael J. Orwat

IPC: C07D417/12 ,  A61K31/357 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4155 ,  A61K31/422 ,  A61K31/423 ,  A61K31/424 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/437 ,  A61K31/438 ,  A61K31/443 ,  A61K31/4525 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/675 ,  C07D261/20 ,  C07D317/48 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  C07D491/107 ,  C07D495/04 ,  C07D495/10 ,  C07D498/04 ,  C07D498/10 ,  C07D513/04 ,  C07F9/6558

Abstract: The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension).

公开(公告)号：US11878975B2

公开(公告)日：2024-01-23

申请号：US16955097

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  John L. Gilmore ,  Tasir Shamsul Haque ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  Shoshana L. Posy ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula ,  Pitani Veera Venkata Srinivas

IPC: C07D471/08 ,  C07D487/08 ,  C07D519/00 ,  C07D471/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07D491/08

CPC classification number: C07D471/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07D491/08

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20220289739A1

公开(公告)日：2022-09-15

申请号：US17609443

申请日：2020-05-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. DYCKMAN ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar ,  Srinivasan Kunchithaptham Duraisamy ,  Pitani Veera Venkata Srinivas ,  Vikram Bhogadi ,  Subramanya Hegde

IPC: C07D471/04 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US11820768B2

公开(公告)日：2023-11-21

申请号：US17245595

申请日：2021-04-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  John L. Gilmore ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Pitani Veera Venkata Srinivas ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula

IPC: C07D471/04 ,  A61K31/437 ,  C07D491/107 ,  C07D471/08 ,  A61P25/00 ,  A61P29/00 ,  A61P19/02 ,  C07D495/10 ,  C07D519/00 ,  A61P37/00

CPC classification number: C07D471/04 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  C07D471/08 ,  C07D491/107 ,  C07D495/10 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I)




N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20230117470A1

公开(公告)日：2023-04-20

申请号：US17773425

申请日：2020-10-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Laxman Pasunoori ,  Sreekantha Ratna Kumar ,  Pitani Veera Venkata Srinivas ,  Vikram Bhogadi ,  Duraisamy Kunchithapatham Srinivasan ,  Anupama Kandhi Ramachandra Reddy ,  Rushith Kumar Anumula ,  Alaric J. Dyckman

IPC: C07D471/04 ,  C07D519/00 ,  C07D417/14

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US11053244B1

公开(公告)日：2021-07-06

申请号：US16910101

申请日：2020-06-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  John L. Gilmore ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Pitani Veera Venkata Srinivas ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula

IPC: C07D471/04 ,  A61K31/437 ,  C07D491/107 ,  C07D471/08 ,  A61P25/00 ,  A61P37/00 ,  A61P19/02 ,  C07D495/10 ,  C07D519/00 ,  A61P29/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US10730877B2

公开(公告)日：2020-08-04

申请号：US16695303

申请日：2019-11-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  John L. Gilmore ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Pitani Veera Venkata Srinivas ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula

IPC: C07D471/04 ,  A61K31/437 ,  C07D491/107 ,  C07D471/08 ,  A61P25/00 ,  A61P37/00 ,  A61P19/02 ,  C07D495/10 ,  C07D519/00 ,  A61P29/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20200095247A1

公开(公告)日：2020-03-26

申请号：US16695303

申请日：2019-11-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  John L. Gilmore ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Pitani Veera Venkata Srinivas ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula

IPC: C07D471/04 ,  C07D491/107 ,  C07D471/08 ,  A61P25/00 ,  A61P29/00 ,  A61P19/02 ,  C07D495/10 ,  C07D519/00 ,  A61P37/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.