公开(公告)号：US20220135550A1

公开(公告)日：2022-05-05

申请号：US17544490

申请日：2021-12-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dean A. WACKER ,  Susheel Jethanand NARA ,  Srinivas CHERUKU ,  Kandhasamy SARKUNAM ,  Firoz Ali JAIPURI ,  Soodamani THANGAVEL ,  Srinivas JOGI ,  Pavan Kalyan KATHI

IPC: C07D413/12 ,  A61P11/00 ,  C07D271/06

Abstract: Disclosed are compounds of Formula (I): or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.