公开(公告)号：US20230348426A1

公开(公告)日：2023-11-02

申请号：US18004731

申请日：2021-07-08

Applicant: Bristol-Myers Squibb Company

Inventor： Pravin Sudhakar Shirude ,  Chandrasekhar Reddy Rachamreddy ,  Amit Kumar Chattopadhyay ,  Balaji Seshadri ,  Vishweshwaraiah Baligar ,  Sudhakara Reddy Madduri ,  Ellen K. Kick ,  Nicholas R. Wurtz

IPC: C07D401/14 ,  C07D401/04 ,  C07D207/14 ,  C07F9/6558 ,  C07D487/08 ,  C07D413/14 ,  C07D405/14 ,  C07D491/107 ,  C07D491/08 ,  C07D403/04 ,  C07D487/04 ,  C07D471/04 ,  C07D498/04 ,  C07F9/572

CPC classification number: C07D401/14 ,  C07D207/14 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/08 ,  C07D491/107 ,  C07D498/04 ,  C07F9/572 ,  C07F9/65583

Abstract: The disclosure relates to compounds of Formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.

公开(公告)号：US20230303513A1

公开(公告)日：2023-09-28

申请号：US18040831

申请日：2021-08-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Pravin Sudhakar Shirude ,  Chandrasekhar Reddy Rachamreddy ,  Vishweshwaraiah Baligar ,  Balaji Seshadri ,  Sudhakara Reddy Madduri ,  Ellen K. Kick ,  Nicholas R. Wurtz

IPC: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  C07D487/08 ,  C07D487/04

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  C07D487/08 ,  C07D487/04

Abstract: The disclosure relates to compounds of Formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases. (I)