公开(公告)号：US20170182050A1

公开(公告)日：2017-06-29

申请号：US15300602

申请日：2015-04-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Kenneth M. Boy ,  Stephen E. Mercer ,  Richard E. Olson ,  Xiaoliang Zhou

IPC: A61K31/517 ,  C07D403/12

CPC classification number: A61K31/517 ,  A61K2121/00 ,  C07D403/12

Abstract: The compound N2-(3-(difluoromethoxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-N4,5,5-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine: [PLEASE INSERT CHEMICAL STRUCTURE HERE] reduces -amyloid peptide (A 42) production and has low potential for bioactivation, and may be useful in the treatment of Alzheimer's Disease and other conditions affected by -amyloid peptide (A 42) production.

公开(公告)号：US09833454B2

公开(公告)日：2017-12-05

申请号：US15300602

申请日：2015-04-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Kenneth M. Boy ,  Stephen E. Mercer ,  Richard E. Olson ,  Xiaoliang Zhou

IPC: C07D239/70 ,  C07D491/00 ,  C07D471/00 ,  C07D413/00 ,  A61K31/517 ,  C07D403/12

CPC classification number: A61K31/517 ,  A61K2121/00 ,  C07D403/12

Abstract: The compound N2-(3-(difluoromethoxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-N4,5,5-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine: [PLEASE INSERT CHEMICAL STRUCTURE HERE] reduces -amyloid peptide (A 42) production and has low potential for bioactivation, and may be useful in the treatment of Alzheimer's Disease and other conditions affected by -amyloid peptide (A 42) production.