公开(公告)号：US3728389A

公开(公告)日：1973-04-17

申请号：US3728389D

申请日：1969-12-15

Applicant: BURROUGHS WELLCOME CO

Inventor： HODSON H ,  RANDALL A

IPC: C07C123/00

CPC classification number: C07C257/18

Abstract: Amidine compounds of the formula

IN WHICH ONE OF Z3 and Z4 is halogen, hydrogen, trifluoromethyl or lower alkoxy when the other is hydrogen; salts of these compounds; their synthesis; and pharmaceutical preparations thereof. Said compounds are useful in the treatment of cardiac arrhythmias.

Abstract translation: 当另一个是氢时，Z 3和Z 4之一的式Ⅺ的脒化合物是卤素，氢，三氟甲基或低级烷氧基; 这些化合物的盐; 他们的合成; 及其药物制剂。 所述化合物可用于治疗心律失常。

公开(公告)号：US3792050A

公开(公告)日：1974-02-12

申请号：US3792050D

申请日：1971-08-26

Applicant: BURROUGHS WELLCOME CO

Inventor： HODSON H ,  RANDALL A

IPC: A61K31/505 ,  C07D217/22 ,  C07D471/04 ,  C07D51/46

CPC classification number: A61K31/505 ,  C07D217/22 ,  C07D471/04 ,  Y10S514/825

Abstract: THE COMPOUNDS 3,4-DIHYDRO-2-OXO-2H-PYRIMIDO (2,1-A) ISOQUINOLINE AND 3,4,6,7-TETRAHYDRO-2-OXO-2H-PYRIMIDO (2,1-A-)ISOQUINOLINE AND ACID ADDITION SALS THEREOF; PHARMACEUTICAL COMPOSITIONS CONTAINING THEM; AND METHODS OF PREPARAING THE COMPOUNDS, SALTS AND PHARMACEUTICAL COMPOSITIONS. THE COMPOUNDS, SALTS AND COMPOSITIONS ARE USE FUL IN THE TREATMENT OF ARTHRITIS.