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公开(公告)号:USRE39240E1
公开(公告)日:2006-08-15
申请号:US09469496
申请日:1999-12-22
申请人: Baldomero M. Olivera , Jean E. F. Rivier , Lourdes J. Cruz , Fe Abogadie , Chris E. Hopkins , John Dykert , Josep L. Torres
发明人: Baldomero M. Olivera , Jean E. F. Rivier , Lourdes J. Cruz , Fe Abogadie , Chris E. Hopkins , John Dykert , Josep L. Torres
IPC分类号: C07K7/08 , C07K14/435
CPC分类号: C07K14/43504 , A61K38/00 , A61K39/00 , C07K14/435
摘要: Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetyl-choline receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defense genes into plant species of interest.
摘要翻译: 提供基本上纯的芋螺毒素,其在神经肌肉接头处抑制突触传递,并且其在体内和测定中都是有用的,因为它们特异性靶向特定受体,例如乙酰胆碱受体和离子通道。 肽的长度可以通过化学合成制成。 它们也可以使用重组DNA技术制备,并且编码具有杀虫性质的这种芋螺毒素的DNA可以作为植物防御基因并入感兴趣的植物物种中。
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公开(公告)号:US5432155A
公开(公告)日:1995-07-11
申请号:US84848
申请日:1993-06-29
申请人: Baldomero M. Olivera , Jean E. F. Rivier , Lourdes J. Cruz , Fe Abogadie , Chris E. Hopkins , John Dykert , Josep L. Torres
发明人: Baldomero M. Olivera , Jean E. F. Rivier , Lourdes J. Cruz , Fe Abogadie , Chris E. Hopkins , John Dykert , Josep L. Torres
IPC分类号: A61K38/00 , A61K39/00 , A61P21/00 , C07K14/435 , C12N15/12 , C07K7/08 , A61K38/10 , A61K38/17
CPC分类号: C07K14/43504 , C07K14/435 , A61K38/00 , A61K39/00
摘要: Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defense genes into plant species of interest.
摘要翻译: 提供基本上纯的芋螺毒素,其抑制神经肌肉接头处的突触传递,并且其在体内和分析中都是有用的,因为它们特异性靶向特定受体,例如乙酰胆碱受体和离子通道。 肽的长度可以通过化学合成制成。 它们也可以使用重组DNA技术制备,并且编码具有杀虫性质的这种芋螺毒素的DNA可以作为植物防御基因并入感兴趣的植物物种中。
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公开(公告)号:US5700778A
公开(公告)日:1997-12-23
申请号:US458499
申请日:1995-06-02
申请人: Baldomero M. Olivera , Jean E.F. Rivier , Lourdes J. Cruz , Fe Abogadie , Chris E. Hopkins , John Dykert , Josep L. Torres
发明人: Baldomero M. Olivera , Jean E.F. Rivier , Lourdes J. Cruz , Fe Abogadie , Chris E. Hopkins , John Dykert , Josep L. Torres
CPC分类号: C07K14/43504 , C07K14/435 , A61K38/00 , A61K39/00
摘要: Substantially pure conotoxins are provided which inhibit synaptic transmissions at the neuromuscular junctions and which are useful both in vivo and in assays because they specifically target particular receptors, such as the acetylcholine receptor, and ion channels. The peptides are of such length that they can be made by chemical synthesis. They also may be made using recombinant DNA techniques, and the DNA encoding such conotoxins having pesticidal properties can be incorporated as plant defense genes into plant species of interest.
摘要翻译: 提供基本上纯的芋螺毒素,其抑制神经肌肉接头处的突触传递,并且其在体内和分析中都是有用的,因为它们特异性靶向特定受体,例如乙酰胆碱受体和离子通道。 肽的长度可以通过化学合成制成。 它们也可以使用重组DNA技术制备,并且编码具有杀虫性质的这种芋螺毒素的DNA可以作为植物防御基因并入感兴趣的植物物种中。
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