公开(公告)号：US09763967B2

公开(公告)日：2017-09-19

申请号：US14561787

申请日：2014-12-05

Applicant: Ball State Innovation Corporation ,  STC.UNM

Inventor： Susan A. McDowell ,  Robert E. Sammelson ,  Larry A. Sklar ,  Mark K. Haynes

IPC: A61K31/415 ,  A61K31/63 ,  A61K31/635

CPC classification number: A61K31/635

Abstract: The present disclosure relates to molecules which function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus and Streptococcus pyogenes.

公开(公告)号：US20180021357A1

公开(公告)日：2018-01-25

申请号：US15691977

申请日：2017-08-31

Applicant: Ball State Innovation Corporation ,  STC.UNM

Inventor： Susan A. McDowell ,  Robert E. Sammelson ,  Larry A. Sklar ,  Mark K. Haynes

IPC: A61K31/635

CPC classification number: A61K31/635

Abstract: The present disclosure relates to molecules that function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus and Streptococcus pyogenes.

公开(公告)号：US10183032B2

公开(公告)日：2019-01-22

申请号：US15691977

申请日：2017-08-31

Applicant: Ball State Innovation Corporation ,  STC.UNM

Inventor： Susan A. McDowell ,  Robert E. Sammelson ,  Larry A. Sklar ,  Mark K. Haynes

IPC: A61K31/415 ,  A61K31/63 ,  A61K31/635

Abstract: The present disclosure relates to molecules that function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus and Streptococcus pyogenes.