公开(公告)号：US08962833B2

公开(公告)日：2015-02-24

申请号：US13699368

申请日：2010-05-25

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D413/12 ,  A61K31/513

CPC分类号： C07D413/12 ,  A61K31/513

摘要： The present invention provides novel salts of raltegravir, processes for their preparation and pharmaceutical compositions comprising them. The present invention also provides crystalline sodium salt of raltegravir, process for its preparation and pharmaceutical compositions comprising it. The present invention further provides a process for the preparation of amorphous sodium salt of raltegravir. The present invention further provides a process for the preparation of raltegravir potassium crystalline form H1.

摘要翻译： 本发明提供了raltegravir的新型盐，其制备方法和包含它们的药物组合物。 本发明还提供了raltegravir的结晶钠盐，其制备方法和包含它的药物组合物。 本发明还提供了制备拉尔维病的无定形钠盐的方法。 本发明进一步提供了制备结晶形式的拉替曲唑钾的方法。

公开(公告)号：US08779143B2

公开(公告)日：2014-07-15

申请号：US13819410

申请日：2010-08-30

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D451/04

CPC分类号： C07D451/04 ,  A61K31/46 ,  C07D471/08

摘要： The present invention provides novel crystalline forms of maraviroc phosphate, processes for their preparation and pharmaceutical compositions comprising them. The present invention also provides novel process for the preparation of maraviroc amorphous form and pharmaceutical composition comprising it.

摘要翻译： 本发明提供新型的Maraviroc磷酸结晶形式，其制备方法和包含它们的药物组合物。 本发明还提供了制备马拉维尔非晶形式的新方法和包含它的药物组合物。

公开(公告)号：US20130072552A1

公开(公告)日：2013-03-21

申请号：US13699096

申请日：2010-05-20

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Bandi Vamsi Krishna ,  Kesireddy Subash Chander Reddy

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Bandi Vamsi Krishna ,  Kesireddy Subash Chander Reddy

IPC分类号： A61K31/34 ,  C07D307/93 ,  C07D493/02

CPC分类号： C07D493/04 ,  C07D307/93

摘要： The present invention provides novel crystalline hydrochloride salt of darunavir, process for its preparation and to pharmaceutical composition comprising it. The present invention also provides novel process for preparation of darunavir amorphous form and pharmaceutical composition comprising it.

公开(公告)号：US20110313035A1

公开(公告)日：2011-12-22

申请号：US13128157

申请日：2009-12-16

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC分类号： A61K31/34 ,  A61P31/12 ,  A61P31/18 ,  C07D493/04

CPC分类号： C07D493/04 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/34

摘要： The present invention provides novel solvated forms of darunavir and processes for there preparation. The present invention also provides novel process for preparation of darunavir amorphous form and pharmaceutical composition comprising it. Thus, for example, darunavir 2-methyl-2-butanol solvate was dissolved in methylene dichloride, distilled under vacuum at 45° C. to obtain a residue, cyclohexane was added to the residue and stirred for 30 hours at 20 to 25° C., and the separated solid was filtered, washed with cyclohexane and dried under vacuum at 50° C. for 12 hours to yield darunavir amorphous form.

摘要翻译： 本发明提供了地瑞那韦的新型溶剂化形式及其制备方法。 本发明还提供了地瑞那韦无定形形式的新方法和包含它的药物组合物。 因此，例如，将地瑞那韦2-甲基-2-丁醇溶剂合物溶解在二氯甲烷中，在45℃下真空蒸馏，得到残留物，将环己烷加入残留物中，在20〜25℃下搅拌30小时 将分离出的固体过滤，用环己烷洗涤，在50℃下真空干燥12小时，得到地瑞那韦非晶形式。

公开(公告)号：US08853430B2

公开(公告)日：2014-10-07

申请号：US13699096

申请日：2010-05-20

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Bandi Vamsi Krishna ,  Kesireddy Subash Chander Reddy

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Bandi Vamsi Krishna ,  Kesireddy Subash Chander Reddy

IPC分类号： C07D493/02 ,  C07D307/93 ,  A61K31/34 ,  C07D493/04

CPC分类号： C07D493/04 ,  C07D307/93

摘要： The present invention provides novel crystalline hydrochloride salt of darunavir, process for its preparation and to pharmaceutical composition comprising it. The present invention also provides novel process for preparation of darunavir amorphous form and pharmaceutical composition comprising it.

摘要翻译： 本发明提供了地瑞那韦的新型结晶盐酸盐，其制备方法和包含其的药物组合物。 本发明还提供了地瑞那韦无定形形式的新方法和包含它的药物组合物。

公开(公告)号：US20130137868A1

公开(公告)日：2013-05-30

申请号：US13699368

申请日：2010-05-25

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D413/12

CPC分类号： C07D413/12 ,  A61K31/513

摘要： The present invention provides novel salts of raltegravir, processes for their preparation and pharmaceutical compositions comprising them. The present invention also provides crystalline sodium salt of raltegravir, process for its preparation and pharmaceutical compositions comprising it. The present invention further provides a process for the preparation of amorphous sodium salt of raltegravir. The present invention further provides a process for the preparation of raltegravir potassium crystalline form H1.

摘要翻译： 本发明提供了raltegravir的新型盐，其制备方法和包含它们的药物组合物。 本发明还提供了raltegravir的结晶钠盐，其制备方法和包含它的药物组合物。 本发明还提供了制备拉尔维病的无定形钠盐的方法。 本发明进一步提供了制备结晶形式的拉替曲唑钾的方法。

公开(公告)号：US09624236B2

公开(公告)日：2017-04-18

申请号：US13530844

申请日：2012-06-22

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC分类号： A01N43/08 ,  A61K31/34 ,  C07D493/04 ,  A61K9/20

CPC分类号： C07D493/04 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/34

摘要： Described herein is pure amorphous darunavir, methods of making pure amorphous darunavir and pharmaceutical compositions containing amorphous darunavir and a pharmaceutically acceptable excipient.

公开(公告)号：US20130211091A1

公开(公告)日：2013-08-15

申请号：US13819410

申请日：2010-08-30

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Rapolu Raji Reddy ,  Kesireddy Subash Chander Reddy ,  Bandi Vamsi Krishna

IPC分类号： C07D451/04

CPC分类号： C07D451/04 ,  A61K31/46 ,  C07D471/08

摘要： The present invention provides novel crystalline forms of maraviroc phosphate, processes for their preparation and pharmaceutical compositions comprising them. The present invention also provides novel process for the preparation of maraviroc amorphous form and pharmaceutical composition comprising it.

摘要翻译： 本发明提供新型的Maraviroc磷酸结晶形式，其制备方法和包含它们的药物组合物。 本发明还提供了制备马拉维尔非晶形式的新方法和包含它的药物组合物。

公开(公告)号：US08552036B2

公开(公告)日：2013-10-08

申请号：US13121443

申请日：2009-01-12

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Rapolu Raji Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Rapolu Raji Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy

IPC分类号： A61K31/4402 ,  C07D213/56

CPC分类号： C07D213/42

摘要： The present invention provides a novel crystalline form of atazanavir sulfate, process for its preparation and to pharmaceutical composition containing it. In accordance with the present invention atazanavir sulfate was dissolved in methanol, to the solution was added ethyl acetate, the solid obtained was collected by filtration and dried to give atazanavir sulfate crystalline form H1.

摘要翻译： 本发明提供了硫酸阿扎那韦的新型结晶形式，其制备方法和含有它的药物组合物。 根据本发明，将阿扎那韦硫酸盐溶于甲醇中，向该溶液中加入乙酸乙酯，过滤收集得到的固体，干燥得到硫酸阿扎那韦结晶形式H1。

公开(公告)号：US20120115857A1

公开(公告)日：2012-05-10

申请号：US13174893

申请日：2011-07-01

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Rapolu Raji Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Rapolu Raji Reddy ,  Dasari Muralidhara Reddy ,  Kesireddy Subash Chander Reddy

IPC分类号： A61K31/536 ,  A61P31/18 ,  C07D265/18

CPC分类号： C07D265/18

摘要： The present invention relates to novel amorphous and crystalline forms of efavirenz, processes for their preparation and pharmaceutical compositions containing them. In accordance with the present invention efavirenz crude is dissolved in acetone at 25° C.-30° C., the solution is slowly added to water for 30 minutes at 0° C.-5° C., stirred for 1 hour at the same temperature, the separated solid is filtered, washed with water and dried at 55° C.-60° C. for 5 hours to give amorphous efavirenz.

摘要翻译： 本发明涉及依法韦仑的新型无定形和结晶形式，其制备方法和含有它们的药物组合物。 根据本发明，依法韦仑粗品在25℃-30℃下溶于丙酮，在0℃-5℃下将溶液缓慢加入水中30分钟，在 相同温度下，将分离的固体过滤，用水洗涤并在55℃-60℃下干燥5小时，得到无定形依法韦仑。