公开(公告)号：US20110212990A1

公开(公告)日：2011-09-01

申请号：US12678793

申请日：2008-11-06

申请人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Rapolu Raji Reddy ,  Dasari Muralidhara Reddy ,  Musku Madhanmohan Reddy ,  Deevireddy Bharath Reddy

发明人： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Rapolu Raji Reddy ,  Dasari Muralidhara Reddy ,  Musku Madhanmohan Reddy ,  Deevireddy Bharath Reddy

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P31/00

CPC分类号： C07D471/04

摘要： The present invention relates to novel polymorph of moxifloxacin hydrochloride, processes for its preparation and to pharmaceutical compositions containing it. Thus, for example moxifloxacin hydrochloride is suspended in methanol and water and the pH is adjusted to 1.0-2.0 with concentrated hydrochloric acid at 25° C. and the separated solid is collected and dried to obtain moxifloxacin hydrochloride monohydrate polymorph IV.

摘要翻译： 本发明涉及盐酸莫西沙星的新型多晶型物，其制备方法和含有它的药物组合物。 因此，例如将莫西沙星盐酸盐悬浮于甲醇和水中，用浓盐酸在25℃将pH调节至1.0-2.0，收集分离的固体并干燥，得到盐酸莫西沙星一水合物多晶型IV。