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    Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
    1.
    发明申请
    Oestrogen-17-sulphamates as inhibitors of steroid sulphatase 有权

    公开(公告)号：US20060281719A1

    公开(公告)日：2006-12-14

    申请号：US11368367

    申请日：2006-03-03

    申请人： Barry Lloyd Potter ,  Michael Reed ,  Lok Woo ,  Hatem Hejaz ,  Bertrand Leblond ,  Matthew Leese ,  Atul Purohit

    发明人： Barry Lloyd Potter ,  Michael Reed ,  Lok Woo ,  Hatem Hejaz ,  Bertrand Leblond ,  Matthew Leese ,  Atul Purohit

    IPC分类号： A61K31/56 ,  C07J1/00

    CPC分类号： A61K31/565 ,  A61K31/37

    摘要： There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII wherein R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.

    Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
    2.
    发明授权
    Oestrogen-17-sulphamates as inhibitors of steroid sulphatase 有权
    雌激素-17-磺酰胺酸盐作为类固醇硫酸酯酶的抑制剂

    公开(公告)号：US08030296B2

    公开(公告)日：2011-10-04

    申请号：US11368367

    申请日：2006-03-03

    申请人： Barry Victor Lloyd Potter ,  Michael John Reed ,  Lok Wai Lawrence Woo ,  Hatem Hejaz ,  Bertrand Leblond ,  Matthew Paul Leese ,  Atul Purohit

    发明人： Barry Victor Lloyd Potter ,  Michael John Reed ,  Lok Wai Lawrence Woo ,  Hatem Hejaz ,  Bertrand Leblond ,  Matthew Paul Leese ,  Atul Purohit

    IPC分类号： A61K31/56 ,  C07J1/00

    CPC分类号： A61K31/565 ,  A61K31/37

    摘要： There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII wherein R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.

    摘要翻译： 提供式I的化合物，其中X是环系; R1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; R2是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; 其中当X是甾体结构且R 1和R 2均为氨基磺酸酯基团时，甾体环体系（X）代表雌激素; 并且其中所述化合物能够抑制类固醇硫酸酯酶（STS）活性和/或能够充当细胞循环的调节剂和/或作为凋亡调节剂和/或细胞生长调节剂。 还提供了式VIII的化合物，其中R 2是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; 并且其中所述化合物能够抑制类固醇硫酸酯酶（STS）活性和/或能够充当细胞循环的调节剂和/或作为凋亡调节剂和/或细胞生长调节剂。