公开(公告)号：US5459063A

公开(公告)日：1995-10-17

申请号：US136743

申请日：1993-10-14

申请人： Barry S. Cooperman ,  Harvey Rubin ,  Jerome Salem ,  Alison L. Fisher

发明人： Barry S. Cooperman ,  Harvey Rubin ,  Jerome Salem ,  Alison L. Fisher

IPC分类号： A61K38/00 ,  C07K14/445 ,  C12N9/02 ,  C12N15/53

CPC分类号： C12N9/0093 ,  C07K14/445 ,  A61K38/00

摘要： This invention relates to the ribonucleotide reductase of Plasmodium falciparum (Pf RR), to the subunits of Pf RR (Pf R1 and Pf R2), and to compounds comprising peptides derived from the Pf R2 C-terminus sequence that inhibit the action of protozoal RR. The invention provides a method for the prevention and treatment of malaria caused by P. falciparum by controlling the proliferation of P. falciparum comprising administering to a patient at least one peptide according to the invention. Antimalarial compositions are provided which comprise a pharmaceutically acceptable carrier and at least one peptide according to the invention which inhibits the P. falciparum ribonucleotide reductase reduction of ribonucleotides to 2'-deoxyribonucleotides. Also provided are methods for diagnosing malaria and for screening potential antimalarial agents.

摘要翻译： 本发明涉及恶性疟原虫（Pf RR）对Pf RR（Pf R1和Pf R2）的亚基的核糖核苷酸还原酶，以及包含抑制原生动物RR作用的Pf R2 C-末端序列的肽的化合物 。 本发明提供了通过控制恶性疟原虫的增殖来预防和治疗由恶性疟原虫引起的疟疾的方法，其包括向患者施用至少一种本发明的肽。 提供了抗疟组合物，其包含药学上可接受的载体和根据本发明的至少一种肽，其将核糖核苷酸的恶性疟原虫核糖核苷酸还原酶还原成2'-脱氧核糖核苷酸。 还提供了诊断疟疾和筛选潜在抗疟药物的方法。