公开(公告)号：US20090143281A1

公开(公告)日：2009-06-04

申请号：US12197031

申请日：2008-08-22

申请人： Barry W. FESTOFF ,  Michael J. Morser

发明人： Barry W. FESTOFF ,  Michael J. Morser

IPC分类号： A61K38/16 ,  A61P25/00

CPC分类号： A61K38/366

摘要： The present invention relates to the use of thrombomodulin analogs for the treatment of trauma-induced spinal cord injury.

摘要翻译： 本发明涉及血栓调节蛋白类似物用于治疗创伤性脊髓损伤的用途。

公开(公告)号：US20230085593A1

公开(公告)日：2023-03-16

申请号：US17837480

申请日：2022-06-10

申请人： Barry W. FESTOFF

发明人： Barry W. FESTOFF

IPC分类号： G01N33/68 ,  G16H10/40 ,  A61B5/151 ,  A61B5/157 ,  A61K38/00 ,  C07K14/47 ,  C07K14/745 ,  C12N15/85 ,  C12Q1/6883

摘要： Blood and bodily fluid reader systems, including circulating biomarkers involving multiple mitochondrial releasates for providing real-time, at-the-scene objective indicia of individuals sustaining mild TBI.

公开(公告)号：US20210140981A1

公开(公告)日：2021-05-13

申请号：US17046606

申请日：2019-04-09

申请人： Barry W. FESTOFF

发明人： Barry W. FESTOFF

IPC分类号： G01N33/68 ,  C12Q1/6883 ,  C12N15/85 ,  C07K14/745 ,  C07K14/47 ,  A61K38/00 ,  A61B5/157 ,  A61B5/151 ,  G16H10/40

摘要： Blood and bodily fluid reader systems, including circulating biomarkers involving multiple mitochondrial releasates for providing real-time, at-the-scene objective indicia of individuals sustaining mild TBI. As a therapeutic component for related neuroin-flammation of mild TBI and related injuries, medicaments, compounds and methods include chimeric proteins which combine: (i) a first polypeptide sequence derived from the “Box A” domain of the “High-Mobility Group Box 1” Protein ( HMGB1) protein; and, (ii) a second polypeptide sequence derived from the D1 lectin-like domain of thrombomodulin (TM). These chimeric proteins both activate and promote certain repair-type functions within the brain, up to and in some cases including the growth of new neuronal fibers and/or the creation of new synaptic junctions; and, keep those types of inflammation-triggered repair processes within healthy and desirable limits.