公开(公告)号：US20100256112A1

公开(公告)日：2010-10-07

申请号：US12754057

申请日：2010-04-05

申请人： Barton James BRADBURY ,  Milind DESHPANDE ,  Akihiro HASHIMOTO ,  Ha Young KIM ,  Edlaine LUCIEN ,  Godwin PAIS ,  Michael PUCCI ,  Qiuping WANG ,  Jason Allan WILES ,  Avinash PHADKE

发明人： Barton James BRADBURY ,  Milind DESHPANDE ,  Akihiro HASHIMOTO ,  Ha Young KIM ,  Edlaine LUCIEN ,  Godwin PAIS ,  Michael PUCCI ,  Qiuping WANG ,  Jason Allan WILES ,  Avinash PHADKE

IPC分类号： A61K31/4743 ,  C07D495/04 ,  A61K31/496 ,  A61P31/04

CPC分类号： A61K31/4743 ,  A61K31/496 ,  C07D495/04 ,  C07D498/16 ,  C07D519/00

摘要： Disclosed herein are hydroxylthienoquinolones and related compounds and their pharmaceutically acceptable salts useful as antiviral agents and having the general formula in which the variables R2, R6, and R7 are defined herein. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity and are particularly efficacious for the treatment of MRSA infections. The invention also provides pharmaceutical compositions, pharmaceutical compositions containing a hydroxylthienoquinolone in combination with one or more other active agent, and methods of treating microbial infections in animals by administering an effective amount of a hydroxylthienoquinolone or related compound to an animal suffering from a microbial infection.

摘要翻译： 本文公开的是羟基噻吩并喹啉酮和相关化合物及其药学上可接受的盐，其可用作抗病毒剂并具有通式，其中变量R2，R6和R7在本文中定义。 本文提供的某些化合物具有有效的抗细菌，抗原生动物或抗真菌活性，并且对于治疗MRSA感染特别有效。 本发明还提供药物组合物，含有羟基噻吩并喹啉与一种或多种其它活性剂的药物组合物，以及通过向有微生物感染的动物施用有效量的羟基噻吩并喹啉酮或相关化合物来治疗动物微生物感染的方法。