公开(公告)号：US10526314B2

公开(公告)日：2020-01-07

申请号：US16098202

申请日：2017-05-02

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Marie-Pierre Collin-Kröpelin ,  Peter Kolkhof ,  Thomas Neubauer ,  Chantal Fürstner ,  Elisabeth Pook ,  Matthias Beat Wittwer ,  Carsten Schmeck ,  Pierre Wasnaire ,  Hanna Tinel ,  Heiko Schirmer

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K45/06

摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-heteroaryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.

公开(公告)号：US12098140B2

公开(公告)日：2024-09-24

申请号：US18134378

申请日：2023-04-13

申请人： Bayer Aktiengesellschaft

发明人： Alexandros Vakalopoulos ,  Marie-Pierre Collin-Kröpelin ,  Nuria Ortega Hernandez ,  Andre Dieskau ,  Melissa Boultadakis-Arapinis ,  Lisa Candish ,  Timo Stellfeld ,  Ilka Mathar ,  Lucas Hudson Hofmeister ,  Peter Sandner ,  Frank Wunder ,  Lisa Dietz ,  Robert Alan Webster ,  Carsten Schmeck ,  Thomas Mondritzki

IPC分类号： C07D401/14 ,  C07D401/04

CPC分类号： C07D401/14 ,  C07D401/04

摘要： The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).