公开(公告)号：US20220267291A1

公开(公告)日：2022-08-25

申请号：US17743534

申请日：2022-05-13

申请人： Bayer Aktiengesellschaft

发明人： Albert SCHNATTERER ,  Michael DOCKNER ,  Peter BRUECHNER ,  Thomas HIMMLER

IPC分类号： C07D317/72 ,  C07D491/113

摘要： The present invention relates to a novel process for the esterification of N-acylated amino acids which contain an acid-labile keto protective group under alkaline conditions without using a polar aprotic solvent, in which the N-acylated amino acid with acid-labile keto protective group prepared in situ is esterified using an alkyl halide or a mono- or dialkyl ester of sulfuric acid.

公开(公告)号：US20210032262A1

公开(公告)日：2021-02-04

申请号：US17046156

申请日：2019-04-03

申请人： Bayer Aktiengesellschaft

发明人： Thomas HIMMLER ,  Peter BRUECHNER ,  Werner LINDNER ,  Julia Johanna HAHN ,  Wahed Ahmed MORADI ,  Reiner FISCHER ,  Michael DOCKNER

IPC分类号： C07D491/113 ,  C07C233/52 ,  C07D209/54 ,  C07C229/48

摘要： The present invention relates to a novel process for preparing substituted cyclohexane amino acid esters and spiroketal-substituted cyclic keto-enols, and to novel intermediates or starting compounds that are passed through or used in the process according to the invention.

公开(公告)号：US20240294539A1

公开(公告)日：2024-09-05

申请号：US18626788

申请日：2024-04-04

申请人： Bayer Aktiengesellschaft

发明人： Thomas HIMMLER ,  Peter BRUECHNER ,  Werner LINDNER ,  Julia Johanna HAHN ,  Wahed Ahmed MORADI ,  Reiner FISCHER ,  Michael DOCKNER

IPC分类号： C07D491/113 ,  C07C229/48 ,  C07C233/52 ,  C07D209/54

CPC分类号： C07D491/113 ,  C07C229/48 ,  C07C233/52 ,  C07D209/54 ,  C07C2601/14 ,  C07C2601/16

摘要： The present invention relates to a novel process for preparing substituted cyclohexane amino acid esters and spiroketal-substituted cyclic keto-enols, and to novel intermediates or starting compounds that are passed through or used in the process according to the invention.

公开(公告)号：US20210139450A1

公开(公告)日：2021-05-13

申请号：US17047994

申请日：2019-04-15

申请人： Bayer Aktiengesellschaft

发明人： Albert SCHNATTERER ,  Michael DOCKNER ,  Peter BRUECHNER ,  Thomas HIMMLER

IPC分类号： C07D317/72 ,  C07D491/113

摘要： The present invention relates to a novel process for the esterification of N-acylated amino acids which contain an acid-labile keto protective group under alkaline conditions without using a polar aprotic solvent, in which the N-acylated amino acid with acid-labile keto protective group prepared in situ is esterified using an alkyl halide or a mono- or dialkyl ester of sulfuric acid.