公开(公告)号：US20170166918A1

公开(公告)日：2017-06-15

申请号：US15122532

申请日：2015-03-10

Applicant: Bayer CropScience LP ,  Bayer CropScience AG

Inventor： Manuel DUBALD ,  Roxanne ARMSTRONG ,  Fabien POREE ,  Cheryl PETERS

IPC: C12N15/82 ,  C12N9/02

CPC classification number: C12N15/8274 ,  C12N9/0069 ,  C12Y113/11027

Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described. A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors. In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.

公开(公告)号：US20170016018A1

公开(公告)日：2017-01-19

申请号：US15124861

申请日：2015-03-09

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT ,  BAYER CROPSCIENCE LP

Inventor： Fabien POREE ,  Bernd LABER ,  Gudrun LANGE ,  Manuel DUBALD ,  Roxanne ARMSTRONG

IPC: C12N15/82 ,  A01N43/713 ,  C12N9/02

CPC classification number: C12N15/8274 ,  A01N43/713 ,  C12N9/0069 ,  C12Y113/11001

Abstract: In the present invention, HPPD enzymes and plants containing them showing a full tolerance against several classes of HPPD-inhibitors are described.A set of HPPD enzymes have been designed which have either no or only a significantly reduced affinity to HPPD inhibitors and, at the same time, the rate of dissociation of the HPPD inhibitors of the enzyme is increased to such an extent that the HPPD inhibitors no longer act as slow-binding or slow, tight-binding inhibitors but, instead of this, have become fully reversible inhibitors.In particular, isolated polynucleotides encoding HPPD inhibitor tolerance polypeptides are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed.

Abstract translation: 特别地，提供了编码HPPD抑制剂耐受多肽的分离的多核苷酸。 另外，包括对应于多核苷酸的氨基酸序列。