公开(公告)号：US20170253602A1

公开(公告)日：2017-09-07

申请号：US15529043

申请日：2015-11-23

申请人： Bayer Pharma Aktiengesellschaft

发明人： Andreas SCHALL ,  Jürgen KLAR ,  Mario LOBELL ,  Hartmut SCHIROK ,  Joachim TELSER ,  Steffen MÜLLER ,  Dirk BROHM ,  Hans BRIEM ,  Hannah JÖRIßEN ,  Joerg KELDENICH (deceased) ,  Michael BÖTTGER ,  Georges DEGENFELD VON ,  Thomas SCHLANGE ,  Ulf BÖMER ,  Niels LINDNER ,  Hanna EILKEN ,  Dmitrij HRISTODOROV ,  Pierre WASNAIRE ,  Kersten Matthias GERICKE ,  Lars BÄRFACKER

IPC分类号： C07D487/04 ,  A61K39/395 ,  A61K31/5513

CPC分类号： C07D487/04 ,  A61K31/5513 ,  A61K39/39558

摘要： The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.