公开(公告)号：US20240158355A1

公开(公告)日：2024-05-16

申请号：US18262037

申请日：2022-01-19

申请人： Baylor College of Medicine

发明人： Martin Matzuk ,  Zhifeng Yu ,  Angela Ku ,  Justin Anglin ,  Feng Li ,  Damian Young ,  Ying-Chu Chen ,  Melek Ucisik ,  John Faver ,  Stephen Palmer ,  Rajesh Sharma ,  Choel Kim

IPC分类号： C07D231/56 ,  C07D401/04 ,  C07D403/04

CPC分类号： C07D231/56 ,  C07D401/04 ,  C07D403/04

摘要： In one aspect, the present disclosure provides compounds which inhibit bromodomain testis (BRDT). In some embodiments, the compounds inhibit bromodomain-2 of BRDT. In another aspect, the present disclosure provides a method of inhibiting BRDT in a male subject, the method comprising administering to the male subject a therapeutically effective amount of a compound of the disclosure. In some embodiments, the method provides a contraceptive effect in the male subject.

公开(公告)号：US20230192606A1

公开(公告)日：2023-06-22

申请号：US17996097

申请日：2021-04-16

申请人： Baylor College of Medicine

发明人： Martin Matzuk ,  Surendra Dawadi ,  Melek Ucisik ,  John Faver ,  Kurt Bohren ,  Feng Li

IPC分类号： C07D207/08 ,  C07D405/12 ,  C07D311/68 ,  C07C279/14

CPC分类号： C07D207/08 ,  C07D405/12 ,  C07D311/68 ,  C07C279/14

摘要： Novel direct thrombin inhibitors are provided herein, along with methods for their use as anticoagulants. The direct thrombin inhibitors described herein are useful in treating and/or preventing thromboembolism and bleeding or clotting disorders. Also provided herein are methods for inhibiting thrombin in a cell using the compounds and compositions described herein.

公开(公告)号：US20220267303A1

公开(公告)日：2022-08-25

申请号：US17618017

申请日：2020-06-20

申请人： Baylor College of Medicine

发明人： Timothy Palzkill ,  Doris Taylor ,  Justin Anglin ,  Nicholas Simmons ,  John Faver ,  Yong Wang ,  Zhuang Jin

IPC分类号： C07D401/14 ,  C07D401/04

摘要： The disclosure relates, in certain aspects, to compounds that can be used to inhibit β-lactamases, such as but not limited to OXA enzymes, such as but not limited to OXA-24, OXA-48, and/or OXA-58. In certain embodiments, these compounds can be used to inhibit activity of β-lactamases in vitro and in vivo.