公开(公告)号：US20170335402A1

公开(公告)日：2017-11-23

申请号：US15502623

申请日：2015-08-08

Applicant: Baylor College of Medicine

Inventor： Rachel Rau ,  Margaret A. Goodell

IPC: C12Q1/68 ,  A61K31/519 ,  A61K31/52

CPC classification number: C12Q1/6886 ,  A61K31/00 ,  A61K31/519 ,  A61K31/52 ,  C07H19/16 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Y201/01037

Abstract: The present disclosure relates to methods of treating AML, associated with DNMT3A mutations by administering one or more DOT1L inhibitors or related pharmaceutical compositions to subjects in need thereof.