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公开(公告)号:US20130012544A1
公开(公告)日:2013-01-10
申请号:US13618026
申请日:2012-09-14
申请人: Beate SCHMIDT , Christian SCHEUFLER , Jürgen VOLZ , Martin FETH , Rolf-Peter HUMMEL , Armin HATZELMANN , Christof ZITT , Andrea WOHLSEN , Degenhard MARX , Hans-Peter KLEY , Deborah OCKERT , Anke HEUSSR , Johannes A.M. CHRISTIAANS , Geert Jan STERK , Wiro M.P.B. MENGE
发明人: Beate SCHMIDT , Christian SCHEUFLER , Jürgen VOLZ , Martin FETH , Rolf-Peter HUMMEL , Armin HATZELMANN , Christof ZITT , Andrea WOHLSEN , Degenhard MARX , Hans-Peter KLEY , Deborah OCKERT , Anke HEUSSR , Johannes A.M. CHRISTIAANS , Geert Jan STERK , Wiro M.P.B. MENGE
IPC分类号: A61K31/454 , A61P3/10 , C07D401/14
CPC分类号: C07D401/14 , A61K31/4152
摘要: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase.
摘要翻译: 化合物1-(2- {4- [3-(3,4-二甲氧基苯基)-4,4-二甲基-5-氧代-4,5-二氢-1H-吡唑-1-基]哌啶-1-基 } -2-氧代乙基)吡咯烷-2,5-二酮是4型磷酸二酯酶的新型有效抑制剂。
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公开(公告)号:US20110269750A1
公开(公告)日:2011-11-03
申请号:US13179895
申请日:2011-07-11
申请人: Hans-Peter KLEY , Guido HANAUER , Daniela HAUSER , Beate SCHMIDT , Dirk BREDENBRÖKER , Wilhelm WURST , Jörg KEMKOWSKI
发明人: Hans-Peter KLEY , Guido HANAUER , Daniela HAUSER , Beate SCHMIDT , Dirk BREDENBRÖKER , Wilhelm WURST , Jörg KEMKOWSKI
IPC分类号: A61K31/4439 , A61P3/10 , A61K31/496 , A61K31/44 , A61K31/538
CPC分类号: A61K45/06 , A61K31/44 , Y10S514/866 , A61K2300/00
摘要: The application relates to specific combinations of Roflumilast and/or Roflumilast N-Oxide and a PPAR-agonist, as well as their use in the treatment of diabetes mellitus type 2.
摘要翻译: 本申请涉及罗氟司特和/或罗氟司特N-氧化物和PPAR激动剂的具体组合,以及它们在治疗2型糖尿病中的用途。
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公开(公告)号:US20100286140A1
公开(公告)日:2010-11-11
申请号:US12766478
申请日:2010-04-23
申请人: Beate SCHMIDT , Steffen WEINBRENNER , Dieter FLOCKERZI , Raimund KUELZER , Hermann TENOR , Hans-Peter KLEY
发明人: Beate SCHMIDT , Steffen WEINBRENNER , Dieter FLOCKERZI , Raimund KUELZER , Hermann TENOR , Hans-Peter KLEY
IPC分类号: A61K31/5377 , A61K31/5025 , A61P11/00
CPC分类号: C07D487/04
摘要: The compounds of formula I in which R1 and R2 have the meanings as given in the description are novel effective PDE2 inhibitors.
摘要翻译: 其中R1和R2具有如说明书中给出的含义的式I化合物是新的有效的PDE2抑制剂。
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