公开(公告)号：US5578073A

公开(公告)日：1996-11-26

申请号：US37335

申请日：1994-09-16

申请人： Beatrice Haimovich ,  Amihay Freeman ,  Ralph Greco

发明人： Beatrice Haimovich ,  Amihay Freeman ,  Ralph Greco

IPC分类号： A61F2/06 ,  A61L33/06 ,  C09D105/08 ,  A61F2/16 ,  C08L5/08

CPC分类号： C09D105/08 ,  A61F2/06 ,  A61L33/062

摘要： A biomaterial with a thromboresistant surface and a method for forming same are provided. The thromboresistant surface is comprised of a distinct coating layer of a chitosan-based membrane and a biologically active material. The biologically active material is capable of converting the chitosan membrane coating from a highly thrombogenic to an essentially non-thrombogenic one. The biologically active material can be a polymeric substance, such as polyvinyl alcohol, forming a polymeric blend with the chitosan, or, can be a biological substance, such as serum albumin, embedded in or attached to the chitosan membrane which has been activated with a treatment of glutardialdehyde. The thromboresistant biomaterial is suitable for use in vascular grafts having an inside diameter of less than 6 millimeters.

摘要翻译： 提供具有抗血栓表面的生物材料及其形成方法。 抗血栓表面由基于壳聚糖的膜和生物活性物质的不同的涂层组成。 生物活性物质能够将壳聚糖膜涂层从高度血栓形成转变为基本上非致血性的。 生物活性材料可以是聚合物质，例如聚乙烯醇，与壳聚糖形成聚合物共混物，或者可以是嵌入或连接到壳聚糖膜上的生物物质，例如血清白蛋白，其已经用 治疗戊二醛。 抗血栓生物材料适用于内径小于6毫米的血管移植物。