公开(公告)号：US20060074233A1

公开(公告)日：2006-04-06

申请号：US11217710

申请日：2005-09-01

申请人： Beth Borowsky ,  Kristine Ogozalek ,  Kenneth Jones

发明人： Beth Borowsky ,  Kristine Ogozalek ,  Kenneth Jones

IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.

公开(公告)号：US20070028315A1

公开(公告)日：2007-02-01

申请号：US11227855

申请日：2005-09-15

申请人： Beth Borowsky ,  Kristine Ogozalek ,  Kenneth Jones

发明人： Beth Borowsky ,  Kristine Ogozalek ,  Kenneth Jones

IPC分类号： A01K67/027 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.

摘要翻译： 本发明提供编码哺乳动物SNORF33受体的分离的核酸，纯化的哺乳动物SNORF33受体，包含编码哺乳动物SNORF33受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF33受体的抗体，用于检测编码哺乳动物SNORF33受体的核酸的核酸探针， 与编码哺乳动物SNORF33受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF33受体的DNA的转基因非人动物，分离哺乳动物SNORF33受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF33受体以及确定化合物与哺乳动物SNORF33受体的结合的方法，识别SNORF33受体的激动剂和拮抗剂的方法，以及所鉴定的激动剂和拮抗剂。