公开(公告)号：US20070299331A1

公开(公告)日：2007-12-27

申请号：US11777958

申请日：2007-07-13

申请人： Beth FRIEDMAN ,  David KLEINFELD ,  Patrick LYDEN ,  Nozomi NISHIMURA ,  Christopher SCHAFFER ,  Lee SCHROEDER ,  Philbert TSAI

发明人： Beth FRIEDMAN ,  David KLEINFELD ,  Patrick LYDEN ,  Nozomi NISHIMURA ,  Christopher SCHAFFER ,  Lee SCHROEDER ,  Philbert TSAI

IPC分类号： A61D99/00

CPC分类号： A61B18/20 ,  A61B18/203 ,  A61B2017/00057 ,  A61B2018/00452

摘要： Ultrashort laser pulses are used to induce photodisruptive breakdown in vasculature in an animal to controllably produce hemorrhage, thrombosis or breach of blood-brain barrier in individual, specifically targeted blood vessels. Damage is limited to the targeted vessels such that neighboring vessels exhibit no signs of vascular damage, including vessels directly above or below the targeted vessel. Ultrashort laser pulses of lower energy are also used to observe and quantify the baseline and altered states of blood flow. Observation and measurement may be performed (1) by TPLSM, OCT or other known techniques, providing a real-time, in vivo model for the dynamics and effects of vascular injury.

摘要翻译： 使用超短激光脉冲来引发动物脉管系统中的光破坏性破坏，从而可控制地产生个体特异性靶向血管中的出血，血栓形成或血脑屏障的破坏。 目标船舶受到的伤害仅限于相邻的船只，没有血管损伤迹象，包括直接在目标船只上方或下方的血管。 较低能量的超短脉冲激光脉冲也用于观察和定量血流的基线和改变的状态。 可以通过TPLSM，OCT或其他已知技术进行观察和测量（1），为血管损伤的动力学和作用提供实时的体内模型。