公开(公告)号：US20210261552A1

公开(公告)日：2021-08-26

申请号：US16973335

申请日：2019-06-06

Applicant: Betta Pharmaceuticals Co., LTD

Inventor： Hao WU ,  Wei GU ,  Xiaojing TANG ,  Wei WANG ,  Bo ZHAN ,  Dongjie FENG ,  Yongxin KE ,  Zhongyan CHEN ,  Yifei SHEN ,  Wenmao WU ,  Xintao ZHAO ,  Hong LAN ,  Jiabing WANG ,  Lieming DING

IPC: C07D487/04 ,  A61P35/00 ,  C07D401/04 ,  C07D417/04 ,  C07D491/20 ,  C07D403/14 ,  C07D487/20 ,  C07D519/00 ,  C07D513/04

Abstract: Disclosed are a compound (as shown in formula I) as an extracellular signal-regulated kinase (ERK) inhibitor, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in treating ERK-mediated diseases. Said compound plays a role by regulating a plurality of processes such as cell proliferation, apoptosis, migration and angiogenesis.