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    AMPLIFICATION ASSAY WITH A PROBE COMPETITOR
    2.
    发明申请
    AMPLIFICATION ASSAY WITH A PROBE COMPETITOR 有权
    具有探测器竞争者的放大测试

    公开(公告)号：US20160362731A1

    公开(公告)日：2016-12-15

    申请号：US15181173

    申请日：2016-06-13

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Samantha Cooper ,  Wei Yang ,  Jennifer Berman

    IPC: C12Q1/68 ,  G06F19/22

    CPC classification number: C12Q1/6827 ,  G06F19/22 ,  C12Q2537/16 ,  C12Q2545/107

    Abstract: Methods and compositions for detecting an allelic form of a target. In an exemplary method, partitions may be created that collectively contain at least one first allelic form and a second allelic form of a target. Each partition may contain (i) a same probe capable of binding specifically to each of the first and second allelic forms of the target and (ii) a competitor configured to bind selectively to the second allelic form relative to the first allelic form and to block binding of the probe to the second allelic form. The first allelic form of the target may be amplified in the partitions. A signal may be detected from a label of the probe while the label is contained by the partitions. A number of partitions that are positive (or negative) for the at least one first allelic form may be determined based on the signal.

    Abstract translation: 用于检测靶标的等位基因形式的方法和组合物。 在示例性方法中，可以创建共同包含目标的至少一个第一等位基因形式和第二等位基因形式的分区。 每个分区可以包含（i）能够特异性结合靶的第一和第二等位基因形式中的每一个的相同探针和（ii）被配置为相对于第一等位基因形式选择性结合第二等位基因形式的竞争物并阻断 探针与第二等位基因形式的结合。 目标的第一个等位基因形式可以在分区中扩增。 当标签被分区包含时，可以从探针的标签检测信号。 可以基于该信号确定对于至少一个第一等位基因形式为正（或负）的多个分区。

    Amplification assay with a probe competitor
    5.
    发明授权
    Amplification assay with a probe competitor 有权

    公开(公告)号：US09868981B2

    公开(公告)日：2018-01-16

    申请号：US15181173

    申请日：2016-06-13

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Samantha Cooper ,  Wei Yang ,  Jennifer Berman

    IPC: C12Q1/68 ,  G06F19/22

    CPC classification number: C12Q1/6827 ,  G06F19/22 ,  C12Q2537/16 ,  C12Q2545/107

    Abstract: Methods and compositions for detecting an allelic form of a target. In an exemplary method, partitions may be created that collectively contain at least one first allelic form and a second allelic form of a target. Each partition may contain (i) a same probe capable of binding specifically to each of the first and second allelic forms of the target and (ii) a competitor configured to bind selectively to the second allelic form relative to the first allelic form and to block binding of the probe to the second allelic form. The first allelic form of the target may be amplified in the partitions. A signal may be detected from a label of the probe while the label is contained by the partitions. A number of partitions that are positive (or negative) for the at least one first allelic form may be determined based on the signal.

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