公开(公告)号：US20250154202A1

公开(公告)日：2025-05-15

申请号：US18834739

申请日：2023-02-02

Applicant: BIONTECH SE

Inventor： Zhengxin DONG ,  Jonathan MCGEE ,  Daniel KALLIN ,  Hans-Ulrich SCHMOLDT ,  Joycelyn WÜSTEHUBE-LAUSCH ,  Jan Patrick BOGEN ,  Klaus KOCH ,  Olaf OTHERSEN ,  Christoph KRESS

IPC: C07K7/64 ,  C07K16/44

Abstract: The present invention relates to cyclic peptides useful as epitope tags, and compositions thereof. Furthermore, the invention is directed to methods of their use in complex formation.

公开(公告)号：US20240009238A1

公开(公告)日：2024-01-11

申请号：US18044955

申请日：2021-09-14

Applicant: BioNTech SE

Inventor： Ugur SAHIN ,  Joycelyn WÜSTEHUBE-LAUSCH ,  Hans-Ulrich SCHMOLDT

IPC: A61K35/17 ,  C07K16/28 ,  C12N5/0783 ,  A61K39/00 ,  A61P35/00

CPC classification number: A61K35/17 ,  C07K16/28 ,  C12N5/0636 ,  A61K39/4633 ,  A61K39/4611 ,  A61P35/00 ,  A61K39/464402 ,  A61K2239/13

Abstract: The invention relates to agents and methods for targeted delivery of payloads to cells. The agents and methods are useful for delivering therapeutic or diagnostic agents to target cells. In one embodiment, the invention involves administering RNA encoding a peptide or polypeptide (docketing compound) comprising a binding moiety (primary targeting moiety) binding to target cells and a further binding moiety (secondary target) binding to an agent that comprises a payload (effector probe). Following expression of the RNA, the primary targeting moiety may bind to a target antigen such as a cancer antigen on cancer cells and then a secondary targeting moiety comprised in the effector probe may target the secondary target to thereby precisely deliver a “payload” to the target cells such as cancer cells.