公开(公告)号：US20240269321A1

公开(公告)日：2024-08-15

申请号：US18246533

申请日：2021-09-30

Applicant: BioNTech SE

Inventor： Heinrich HAAS ,  Sebastian HÖRNER ,  Thomas Michael HILLER ,  Tobias KIND ,  Tijana BACIC

IPC: A61K48/00 ,  A61K47/26 ,  A61K47/54 ,  A61K47/69

CPC classification number: A61K48/0033 ,  A61K47/26 ,  A61K47/543 ,  A61K47/547 ,  A61K47/548 ,  A61K47/6911

Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.

公开(公告)号：US20220143069A1

公开(公告)日：2022-05-12

申请号：US17593391

申请日：2020-04-01

Applicant: BIONTECH SE

Inventor： Heinrich HAAS ,  Sebastian HÖRNER ,  Thomas Michael HILLER

IPC: A61K31/7105 ,  A61K47/18 ,  A61K47/02 ,  A61K47/26 ,  A61K47/22

Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.