公开(公告)号：US20230099898A1

公开(公告)日：2023-03-30

申请号：US17904937

申请日：2021-02-26

Applicant: BioNTech SE ,  Johannes Gutenberg-Universitat Mainz

Inventor： Heinrich HAAS ,  Sara NOGUEIRA ,  Peter LANGGUTH ,  Christian SIEWERT ,  Vera CORNET

IPC: A61K9/16 ,  C12N15/88 ,  A61K31/7105

Abstract: The present disclosure relates to RNA particles for delivery of RNA to target tissues after administration, in particular after parenteral administration such as intramuscular, intravenous, subcutaneous or intratumoral administration, and compositions comprising such RNA particles. The present disclosure, in particular, relates to RNA particles comprising RNA, at least one cationic or cationically ionizable lipid or lipid-like material, and at least one cationic polymer, wherein the particles do not have a core-shell structure.