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公开(公告)号：US20240252471A1
公开(公告)日：2024-08-01
申请号：US18526686
申请日：2023-12-01
发明人： Vasukumar KAKUMANU , David Christian HANLEY , Frank YOCCA , Chetan Dalpatbhai LATHIA , Lavanya RAJACHANDRAN , Robert RISINGER
IPC分类号： A61K31/4174 , A61K9/00 , A61K47/38 , A61P25/18 , A61P25/20
CPC分类号： A61K31/4174 , A61K9/006 , A61K47/38 , A61P25/18 , A61P25/20
摘要： Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.
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公开(公告)号：US20240245650A1
公开(公告)日：2024-07-25
申请号：US18176296
申请日：2023-02-28
发明人： Vasukumar KAKUMANU , David Christian HANLEY , Frank YOCCA , Chetan Dalpatbhai LATHIA , Lavanya RAJACHANDRAN , Robert RISINGER
IPC分类号： A61K31/4174 , A61K9/00 , A61K47/38 , A61P25/18 , A61P25/20
CPC分类号： A61K31/4174 , A61K9/006 , A61K47/38 , A61P25/18 , A61P25/20
摘要： Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.
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公开(公告)号：US20240173299A1
公开(公告)日：2024-05-30
申请号：US18430003
申请日：2024-02-01
发明人： Vasukumar KAKUMANU , David Christian HANLEY , Frank YOCCA , Chetan Dalpatbhai LATHIA , Lavanya RAJACHANDRAN , Robert RISINGER
IPC分类号： A61K31/4174 , A61K9/00 , A61K9/06 , A61K9/20 , A61K9/70 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/38 , A61K47/44 , A61P25/18 , A61P25/20 , A61P25/36
CPC分类号： A61K31/4174 , A61K9/006 , A61K9/06 , A61K9/2013 , A61K9/2018 , A61K9/7007 , A61K9/7015 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/38 , A61K47/44 , A61P25/18 , A61P25/20 , A61P25/36
摘要： Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.
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公开(公告)号：US20240024288A1
公开(公告)日：2024-01-25
申请号：US17628021
申请日：2020-07-17
发明人： Vasukumar KAKUMANU , David Christian HANLEY , Frank YOCCA , Chetan Dalpatbhai LATHIA , Scott David BARNHART , Lavanya RAJACHANDRAN , Robert RISINGER
IPC分类号： A61K31/4174 , A61P25/18 , A61K9/00 , A61P25/20 , A61P25/36
CPC分类号： A61K31/4174 , A61P25/18 , A61K9/006 , A61P25/20 , A61P25/36
摘要： Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.
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公开(公告)号：US20230338339A1
公开(公告)日：2023-10-26
申请号：US18216890
申请日：2023-06-30
发明人： Vasukumar KAKUMANU , David Christian HANLEY , Frank YOCCA , Chetan Dalpatbhai LATHIA , Lavanya RAJACHANDRAN , Robert RISINGER
IPC分类号： A61K31/4174 , A61P25/18 , A61K9/00 , A61K9/06 , A61K9/20 , A61K9/70 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/38 , A61K47/44
CPC分类号： A61K31/4174 , A61P25/18 , A61K9/006 , A61K9/06 , A61K9/2013 , A61K9/2018 , A61K9/7007 , A61K9/7015 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/38 , A61K47/44
摘要： Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.
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公开(公告)号：US20230118091A1
公开(公告)日：2023-04-20
申请号：US17993422
申请日：2022-11-23
发明人： Vasukumar KAKUMANU , David Christian HANLEY , Frank YOCCA , Chetan Dalpatbhai LATHIA , Scott David BARNHART , Lavanya RAJACHANDRAN , Robert RISINGER
IPC分类号： A61K31/4174 , A61K9/00 , A61K9/70 , A61P25/18 , A61K47/38 , A61K47/10 , A61K47/26 , A61K47/44 , A61K47/34 , A61K9/20 , A61K9/06
摘要： Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.
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公开(公告)号：US20240277669A1
公开(公告)日：2024-08-22
申请号：US18600419
申请日：2024-03-08
发明人： Vasukumar KAKUMANU , David Christian HANLEY , Frank YOCCA , Chetan Dalpatbhai LATHIA , Lavanya RAJACHANDRAN , Robert RISINGER
IPC分类号： A61K31/4174 , A61K9/00 , A61K47/38 , A61P25/18 , A61P25/20
CPC分类号： A61K31/4174 , A61K9/006 , A61K47/38 , A61P25/18 , A61P25/20
摘要： Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.
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公开(公告)号：US20240245651A1
公开(公告)日：2024-07-25
申请号：US18600431
申请日：2024-03-08
发明人： Vasukumar KAKUMANU , David Christian HANLEY , Frank YOCCA , Chetan Dalpatbhai LATHIA , Lavanya RAJACHANDRAN , Robert RISINGER
IPC分类号： A61K31/4174 , A61K9/00 , A61K47/38 , A61P25/18 , A61P25/20
CPC分类号： A61K31/4174 , A61K9/006 , A61K47/38 , A61P25/18 , A61P25/20
摘要： Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.
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公开(公告)号：US20240197684A1
公开(公告)日：2024-06-20
申请号：US18443689
申请日：2024-02-16
发明人： Vasukumar KAKUMANU , David Christian HANLEY , Frank YOCCA , Chetan Dalpatbhai LATHIA , Lavanya RAJACHANDRAN , Robert RISINGER
IPC分类号： A61K31/4174 , A61K9/00 , A61K9/06 , A61K9/20 , A61K9/70 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/38 , A61K47/44 , A61P25/18 , A61P25/20 , A61P25/36
CPC分类号： A61K31/4174 , A61K9/006 , A61K9/06 , A61K9/2013 , A61K9/2018 , A61K9/7007 , A61K9/7015 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/38 , A61K47/44 , A61P25/18 , A61P25/20 , A61P25/36
摘要： Disclosed herein are methods of administering relatively high doses of dexmedetomidine or a pharmaceutically acceptable salt thereof to a human subject, without also inducing significant sedation. The disclosed methods are particularly suitable for the treatment of agitation, especially when associated with neurodegenerative and/or neuropsychiatric diseases such as schizophrenia, bipolar illness such as bipolar disorder or mania, dementia, depression, or delirium.
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公开(公告)号：US20240024289A1
公开(公告)日：2024-01-25
申请号：US18030405
申请日：2021-10-08
发明人： Frank YOCCA , Robert RISINGER , Michael DE VIVO , Friso POSTMA
IPC分类号： A61K31/4174 , A61P25/18 , A61K9/00
CPC分类号： A61K31/4174 , A61P25/18 , A61K9/006
摘要： Disclosed herein are methods and composition for treating bipolar disorders and psychosis by administering dexmedetomidine. The methods and composition alleviate mania, hypomania, psychosis, and depression in the subjects, providing improved therapeutic outcomes.
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